Biochemical and histopathological investigation of the protective effect of disulfiram in ischemia-induced ovary damage.
Gynecol Endocrinol
; 28(2): 143-7, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-21756070
ABSTRACT
It was biochemically and histopathologically investigated whether disulfiram has protective effects on ischemia-induced ovary damage. For this purpose, levels of tGSH, superoxide dismutase (SOD), malondialdehyde (MDA), and 8-OH Gua/Gua were investigated in ischemic rat ovary tissue. Results show that used doses of disulfiram (10, 25, and 50 mg/kg) prevent MDA, a product of ischemia-induced lipid peroxidation, formation in female rat ovary tissue and prevent decrease of enzymatic and non-enzymatic (SOD, GSH) antioxidant parameters. Additionally, all doses of disulfiram significantly prevent DNA damage when compared to control group. Fewer histopathological findings were observed in tissues with higher antioxidant levels and lower oxidant and DNA damage levels.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Ovarianas
/
Ovário
/
Substâncias Protetoras
/
Dissulfiram
/
Inibidores Enzimáticos
/
Isquemia
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Gynecol Endocrinol
Assunto da revista:
ENDOCRINOLOGIA
/
GINECOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Turquia