The different roles of ER subtypes in cancer biology and therapy.
Nat Rev Cancer
; 11(8): 597-608, 2011 Jul 22.
Article
em En
| MEDLINE
| ID: mdl-21779010
ABSTRACT
By eliciting distinct transcriptional responses, the oestrogen receptors (ERs) ERα and ERß exert opposite effects on cellular processes that include proliferation, apoptosis and migration and that differentially influence the development and the progression of cancer. Perturbation of ER subtype-specific expression has been detected in various types of cancer, and the differences in the expression of ERs are correlated with the clinical outcome. The changes in the bioavailability of ERs in tumours, together with their specific biological functions, promote the selective restoration of their activity as one of the major therapeutic approaches for hormone-dependent cancers.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptor alfa de Estrogênio
/
Receptor beta de Estrogênio
/
Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Cancer
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos