Plasma leptin and adiponectin concentrations in healthy, non-obese children.
J Pediatr Endocrinol Metab
; 24(5-6): 313-8, 2011.
Article
em En
| MEDLINE
| ID: mdl-21823529
ABSTRACT
BACKGROUND:
Alterations in plasma leptin and adiponectin concentrations are associated with an adverse metabolic profile in obese children.OBJECTIVE:
To simultaneously assess multiple factors with possible effects on plasma leptin and adiponectin concentrations in healthy, non-obese children.SUBJECTS:
We studied 170 healthy non-obese children (86 males, age 10+1.5 years), with available medical records from birth.METHODS:
Plasma leptin and adiponectin concentrations were assessed by immunoassay. The ratio of current weight/birth weight (WBWR) was used as an index of children growth from birth. Children's intensity of physical activity and parental characteristics were also assessed.RESULTS:
Leptin was positively associated with WBWR (p<0.0001); parental smoking (analysis of variance, ANOVA; p-=0.03) and parental obesity (ANOVA; p<0.001) were negatively associated with breastfeeding (p<0.01) and children's access to exercise (p<0.0001). Adiponectin was negatively associated with WBWR (p<0.0001) and parental smoking (p=0.04), with an additive negative effect of parental smoking status and parental obesity on children's adiponectin levels (ANOVA; p=0.02).CONCLUSIONS:
Children's and parental factors are related and could possibly influence leptin and adiponectin concentrations in healthy non-obese children. Early preventive strategies that target both children and parents could improve the profile of adipocytokine in these children.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leptina
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Child
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Pediatr Endocrinol Metab
Assunto da revista:
ENDOCRINOLOGIA
/
PEDIATRIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Grécia