Identification of cardiovascular microRNA targetomes.
J Mol Cell Cardiol
; 51(5): 674-81, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21888912
ABSTRACT
MicroRNAs (miRNAs) are strong post-transcriptional regulators targeting multiple targets. Endogenously transcribed, miRNAs specifically bind to complementary sequences of mRNAs and repress their expression thus govern control of cellular signaling pathways. An altered miRNA expression is causally related to cardiovascular disease. Identification of miRNA-dependent pathways is therefore an important aim to develop new therapeutic approaches. To understand miRNA function in various cardiovascular cells, the identification of individual miRNA target genes is of utmost importance. Indeed, the biological function of a miRNA is dependent on the availability of potential targets in a cell. We here summarize and discuss current challenging approaches to identify miRNA targetomes which will help to understand miRNA function in cardiac homeostasis and disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
Doenças Cardiovasculares
/
Regulação da Expressão Gênica
/
Biologia Computacional
/
MicroRNAs
/
Proteômica
/
Miocárdio
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Mol Cell Cardiol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Alemanha