Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction.
Bioorg Med Chem Lett
; 22(1): 683-8, 2012 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-22104152
ABSTRACT
Bioassay-guided fractionation of two cyanobacterial extracts from Papua New Guinea has yielded hoiamide D in both its carboxylic acid and conjugate base forms. Hoiamide D is a polyketide synthase (PKS)/non-ribosomal peptide synthetase (NRPS)-derived natural product that features two consecutive thiazolines and a thiazole, as well as a modified isoleucine residue. Hoiamide D displayed inhibitory activity against p53/MDM2 interaction (EC(50)=4.5 µM), an attractive target for anticancer drug development.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Proteína Supressora de Tumor p53
/
Cianobactérias
/
Depsipeptídeos
/
Proteínas Proto-Oncogênicas c-mdm2
/
Tiazolidinas
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos