FLU, a negative feedback regulator of tetrapyrrole biosynthesis, is physically linked to the final steps of the Mg(++)-branch of this pathway.
FEBS Lett
; 586(3): 211-6, 2012 Feb 03.
Article
em En
| MEDLINE
| ID: mdl-22212719
ABSTRACT
Regulation of tetrapyrrole biosynthesis in higher plants has been attributed to negative feedback control. Two effectors of feedback inhibition have been identified, heme and the FLU protein. Inhibition by heme implicates the Fe-branch via regulation of the initial step of tetrapyrrole synthesis. In the present work a FLU-containing chloroplast membrane complex was identified, that besides FLU comprises the four enzymes catalyzing the final steps of chlorophyll synthesis. The results support the notion that FLU links chlorophyll synthesis and the target of feedback control, glutamyl-tRNA reductase, thereby allowing also the Mg-branch to control the initial step of tetrapyrrole synthesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Clorofila
/
Arabidopsis
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Proteínas de Arabidopsis
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Retroalimentação Fisiológica
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Magnésio
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Suíça