Prostate-specific antigen concentration in young men: new estimates and review of the literature.
BJU Int
; 110(11): 1627-35, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22502603
ABSTRACT
UNLABELLED Study Type--Diagnostic (cohort) Level of Evidence 2b. What's known on the subject? and What does the study add? Although non-recommended PSA testing has been reported in men younger than 40 years of age, there are few recognized data on PSA in younger American men, particularly younger African-American men, to provide age- and race-specific references. Using data from an existing large study of young, male members of the US military, aged 28-36 years, the present study provides PSA reference distributions for young Caucasian-American men (median = 0.56, 95th percentile = 1.42, range <0.01-3.34 ng/mL) and African-American men (median = 0.64, 95th percentile = 1.89, range 0.12-6.45 ng/mL). Previous estimates from the literature are also summarized. OBJECTIVE:
⢠To provide race-specific prostate-specific antigen (PSA) reference distributions for young men less than 40 years of age who might have undergone non-recommended PSA testing because of their family history of prostate cancer or inadvertently as part of a standard panel of tests. MATERIALS ANDMETHODS:
⢠We used data from a large existing study of young, male Caucasian- and African-American members of the US military with stored serum in the Department of Defense serum repository. ⢠As part of this previous study, we selected a random sample of 373 Caucasian- and 366 African-American men aged 28-36 years with an archived serum specimen collected for standard military purposes from 2004 to 2006. ⢠We measured serum total PSA concentration in this specimen using the Beckman Coulter Access Hybritech PSA assay.RESULTS:
⢠The PSA level ranged from <0.01 to 3.34 ng/mL among Caucasian-American men, with a median of 0.56 ng/mL and a 95th percentile of 1.42 ng/mL. ⢠The PSA level ranged from 0.12 to 6.45 ng/mL among African-American men, with a median of 0.64 ng/mL and 95th percentile of 1.89 ng/mL. ⢠The PSA level was significantly higher in African- than in Caucasian-American men (P= 0.001).CONCLUSION:
⢠The PSA estimates, together with those summarized from the literature, provide age- and race-specific PSA reference distributions for young men who might have undergone non-recommended PSA testing. ⢠Comparisons by race could also begin to inform the timing of divergence of prostate cancer risk by race.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Negro ou Afro-Americano
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Antígeno Prostático Específico
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População Branca
Tipo de estudo:
Etiology_studies
/
Incidence_studies
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Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Humans
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Male
País/Região como assunto:
America do norte
Idioma:
En
Revista:
BJU Int
Assunto da revista:
UROLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos