Prevalence of celiac disease in Indian children with Down syndrome and its clinical and laboratory predictors.
Indian J Pediatr
; 80(2): 114-7, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-22791400
ABSTRACT
OBJECTIVE:
To study the prevalence of celiac disease in Indian children with Down syndrome and evaluate its clinical and laboratory predictors.METHODS:
Prevalence of celiac disease (CD) was assessed in 100 patients with Down syndrome (DS) attending pediatric genetic clinic at All India Institute of Medical Sciences,in a prospective observational study, based on the characteristic symptomatology, positive indirect immunofluorescence anti endomyseal antibody(anti EMA) test and duodenal histology based on adapted Marsh criteria. Clinical and laboratory features were compared in children having both CD and DS and those with DS alone.RESULTS:
Anti EMA was positive in 7 out of 100 patients screened for CD; 6 in whom the duodenal biopsy could be done showed histopathological features consistent with celiac disease. Amongst various clinical features evaluated as possible risk factors; pallor reached statistical significance (OR = 7.04 95%CI 1.08-45.7). In addition anemia (Hb <11 g%) was significantly associated with CD (p = 0.06).CONCLUSIONS:
The present results showed a high prevalence of CD in DS children in a tertiary hospital in India and low hemoglobin to be an important risk factor. The authors recommend that all Indian children with Down syndrome, particularly those with anemia should be screened for celiac disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença Celíaca
/
Síndrome de Down
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Indian J Pediatr
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Índia