Internal catalase protects herpes simplex virus from inactivation by hydrogen peroxide.
J Virol
; 86(21): 11931-4, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-22915822
ABSTRACT
Herpes simplex virus 1 (HSV-1) was shown to contain catalase, an enzyme able to detoxify hydrogen peroxide by converting it to water and oxygen. Studies with a catalase inhibitor indicated that virus-associated catalase can have a role in protecting the virus from oxidative inactivation. HSV-1 was found to be more sensitive to killing by hydrogen peroxide in the presence of a catalase inhibitor than in its absence. The results suggest a protective role for catalase during the time HSV-1 spends in the oxidizing environment outside a host cell.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Virais
/
Catalase
/
Herpesvirus Humano 1
/
Desinfetantes
/
Peróxido de Hidrogênio
Limite:
Animals
Idioma:
En
Revista:
J Virol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos