Bromophycoic acids: bioactive natural products from a Fijian red alga Callophycus sp.
J Org Chem
; 77(18): 8000-6, 2012 Sep 21.
Article
em En
| MEDLINE
| ID: mdl-22920243
ABSTRACT
Bioassay-guided fractionation of extracts from a Fijian red alga in the genus Callophycus resulted in the isolation of five new compounds of the diterpene-benzoate class. Bromophycoic acids A-E (1-5) were characterized by NMR and mass spectroscopic analyses and represent two novel carbon skeletons, one with an unusual proposed biosynthesis. These compounds display a range of activities against human tumor cell lines, malarial parasites, and bacterial pathogens including low micromolar suppression of MRSA and VREF.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzoatos
/
Produtos Biológicos
/
Diterpenos
Limite:
Humans
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos