SAPIN: a framework for the structural analysis of protein interaction networks.
Bioinformatics
; 28(22): 2998-9, 2012 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-22954630
ABSTRACT
SUMMARY:
Protein interaction networks are widely used to depict the relationships between proteins. These networks often lack the information on physical binary interactions, and they do not inform whether there is incompatibility of structure between binding partners. Here, we introduce SAPIN, a framework dedicated to the structural analysis of protein interaction networks. SAPIN first identifies the protein parts that could be involved in the interaction and provides template structures. Next, SAPIN performs structural superimpositions to identify compatible and mutually exclusive interactions. Finally, the results are displayed using Cytoscape Web.AVAILABILITY:
The SAPIN server is available at http//sapin.crg.es. CONTACT jae-seong.yang@crg.eu or christina.kiel@crg.eu. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics Online.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Software
/
Proteínas
/
Mapas de Interação de Proteínas
Limite:
Humans
Idioma:
En
Revista:
Bioinformatics
Assunto da revista:
INFORMATICA MEDICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Espanha