Systemic absorption of clindamycin following intravaginal application of clindamycin phosphate 1% cream.
J Clin Pharmacol
; 30(1): 33-8, 1990 Jan.
Article
em En
| MEDLINE
| ID: mdl-2303578
ABSTRACT
The extent to which clindamycin is absorbed systemically following intravaginal application of clindamycin phosphate 1% cream was assessed in 12 healthy female volunteers. Each subject received a single intravenous dose of clindamycin phosphate sterile solution (48 mg). A week later, each subject received 50 mg (5 mL) doses of intravaginal cream according to one of two dosage regimens once daily (qd) for seven consecutive doses or twice daily (q12hr) for 13 consecutive doses. Steady state was achieved on or before day 4 for both regimens. The absolute bioavailabilities of the two intravaginal treatments were 6% for qd dosing and 13% for q12hr dosing, indicating that only a small fraction of the intravaginal dose is absorbed systemically.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Clindamicina
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
J Clin Pharmacol
Ano de publicação:
1990
Tipo de documento:
Article