Enhanced carcinogenicity by coexposure to arsenic and iron and a novel remediation system for the elements in well drinking water.
Arch Toxicol
; 87(3): 439-47, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23100159
ABSTRACT
Various carcinomas including skin cancer are explosively increasing in arsenicosis patients who drink arsenic-polluted well water, especially in Bangladesh. Although well drinking water in the cancer-prone areas contains various elements, very little is known about the effects of elements except arsenic on carcinogenicity. In order to clarify the carcinogenic effects of coexposure to arsenic and iron, anchorage-independent growth and invasion in human untransformed HaCaT and transformed A431 keratinocytes were examined. Since the mean ratio of arsenic and iron in well water was 110 in cancer-prone areas of Bangladesh, effects of 1 µM arsenic and 10 µM iron were investigated. Iron synergistically promoted arsenic-mediated anchorage-independent growth in untransformed and transformed keratinocytes. Iron additionally increased invasion in both types of keratinocytes. Activities of c-SRC and ERK that regulate anchorage-independent growth and invasion were synergistically enhanced in both types of keratinocytes. Our results suggest that iron promotes arsenic-mediated transformation of untransformed keratinocytes and progression of transformed keratinocytes. We then developed a low-cost and high-performance adsorbent composed of a hydrotalcite-like compound for arsenic and iron. The adsorbent rapidly reduced concentrations of both elements from well drinking water in cancer-prone areas of Bangladesh to levels less than those in WHO health-based guidelines for drinking water. Thus, we not only demonstrated for the first time increased carcinogenicity by coexposure to arsenic and iron but also proposed a novel remediation system for well drinking water.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Poluentes Químicos da Água
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Água Potável
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Queratinócitos
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Transformação Celular Neoplásica
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Quelantes
/
Compostos de Sódio
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Compostos de Ferro
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Arsenitos
/
Recuperação e Remediação Ambiental
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Arch Toxicol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Japão