Unusual 9,19 : 24,32-dicyclotetracyclic triterpenoids from Lygodium japonicum.

ABSTRACT

Lygodipenoids A (1) and B (2), two novel C33 tetracyclic triterpenoids with a new 9,19  24,32-dicyclopropane skeleton, were isolated from the whole grass of Lygodium japonicum. Their structures were elucidated by spectroscopic and chemical means. Compounds 1 and 2 were tested in transfected cultured human embryonic kidney 293 HEK293 cells for an agonist assay, and compound 1 was identified as a partial agonist for liver X receptor α.