Hsa-miR-499 rs3746444 polymorphism contributes to cancer risk: a meta-analysis of 12 studies.
PLoS One
; 7(12): e50887, 2012.
Article
em En
| MEDLINE
| ID: mdl-23236400
ABSTRACT
BACKGROUND:
Single nucleotide polymorphisms (SNPs) occurred in pre-microRNAs or targets of microRNAs (miRs) may contribute to cancer risks. Since 2007, many studies have investigated the association between common SNPs located on hsa-miR-499 (rs3746444) and cancer risks; however, the results were inconclusive. METHODOLOGY/PRINCIPALFINDINGS:
We conducted a meta-analysis of 12 studies that included 5765 cases and 7076 controls to identify the strength of association. Odds ratio (OR) and 95% confidence intervals (95% CI) were used to assess the strength of association. Overall, individuals with the variant AG (ORâ=â1.215, 95% CI 1.027, 1.437; P(heterogeneity)<0.01) and AG/GG (ORâ=â1.227, 95% CI 1.046, 1.439; P(heterogeneity)<0.01) genotypes were associated with a significantly increased risk of cancer than those with wild AA genotype. Sub-group analysis revealed that the variant AG (ORâ=â1.411, 95% CI 1.142, 1.745; P(heterogeneity)â=â0.01) and AG/GG (ORâ=â1.413, 95% CI 1.163, 1.717, P(heterogeneity)â=â0.01) genotypes still showed an increased risk of cancer in Asians; however, a trend of reduced risk of cancer was observed in Caucasians (AG vs. AA ORâ=â0.948, 955 CI 0.851, 1.057, P(heterogeneity)â=â0.12; AG/GG vs. AA ORâ=â0.959, 95% CI 0.865, 1.064; P(heterogeneity)â=â0.19). Meta-regression showed that ethnicity (pâ=â0.048) and sample size (pâ=â0.02) but not cancer types (pâ=â0.89) or source of control (pâ=â0.97) were the sources of heterogeneity.CONCLUSIONS:
These meta-analysis results suggest that hsa-miR-499 polymorphism rs3746444 is associated with a significantly increased risk of cancer, especially in Asian populations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
MicroRNAs
/
Neoplasias
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
PLoS One
Assunto da revista:
CIENCIA
/
MEDICINA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China