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Molecular characterization, tissue distribution and kinetic analysis of carnitine palmitoyltransferase I in juvenile yellow catfish Pelteobagrus fulvidraco.
Zheng, Jia-Lang; Luo, Zhi; Zhu, Qing-Ling; Chen, Qi-Liang; Gong, Yuan.
Afiliação
  • Zheng JL; Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Genomics ; 101(3): 195-203, 2013 Mar.
Article em En | MEDLINE | ID: mdl-23238057
ABSTRACT
Up to date, only limited information is available on genetically and functionally different isoforms of CPT I enzyme in fish. In the study, molecular characterization and their tissue expression profile of three CPT Iα isoforms (CPT Iα1a, CPT Iα1b and CPT Iα2a) and a CPT Iß isoform from yellow catfish Pelteobagrus fulvidraco is determined. The activities and kinetic features of CPT I from several tissues have also been analyzed. The four CPT I isoforms in yellow catfish present distinct differences in amino acid sequences and structure. They are widely expressed in liver, heart, white muscle, spleen, intestine and mesenteric adipose tissue of yellow catfish at the mRNA level, but with the varying levels. CPT I activity and kinetics show tissue-specific differences stemming from co-expression of different isoforms, indicating more complex pathways of lipid utilization in fish than in mammals, allowing for precise control of lipid oxidation in individual tissue.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carnitina O-Palmitoiltransferase / Isoformas de Proteínas Idioma: En Revista: Genomics Assunto da revista: GENETICA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carnitina O-Palmitoiltransferase / Isoformas de Proteínas Idioma: En Revista: Genomics Assunto da revista: GENETICA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: China