Uptake of botulinum neurotoxin in the intestine.
Curr Top Microbiol Immunol
; 364: 45-59, 2013.
Article
em En
| MEDLINE
| ID: mdl-23239348
ABSTRACT
Foodborne and intestinal botulism are the most common forms of human botulism; both result from the absorption of botulinum neurotoxin (BoNT) from the digestive tract into the circulation. BoNT is a large protein toxin (approximately 150 kDa), but it is able to pass through the epithelial barrier in the digestive tract. Recent cellular and molecular biology studies have begun to unravel the mechanisms by which this large protein toxin crosses the intestinal epithelial barrier. This review provides an overview of current knowledge relating to the absorption of botulinum toxins (BoNT and BoNT complex) from the gastrointestinal tract, with particular emphasis on the interaction of these toxins with the intestinal epithelial barrier.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxinas Botulínicas
/
Mucosa Intestinal
/
Neurotoxinas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Top Microbiol Immunol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Japão