[Genetic markers of individual susceptibility and oxidative stress in subjects exposed to low dose of benzene. Preliminary data]. / Indicatori genetici di suscettibilità individuale e stress ossidativo in soggetti esposti a basse dosi di benzene. Dati preliminari.
G Ital Med Lav Ergon
; 33(3 Suppl): 35-8, 2011.
Article
em It
| MEDLINE
| ID: mdl-23393795
ABSTRACT
In the present study we used AOPPs and AGE as early markers of oxidative stress in refinery oil workers. In addition we evaluated whether a genetically determined reduction in the ability to detoxify electrophilic compounds, such as that expected among individuals with glutathione S-transferase (GST) null genotypes might influence the levels of AOPPs thus increasing toxicity. The study was performed on 25 oil refinery workers and in 18 age-matched control subjects. We found a statistically significant increase of AOPPs in exposed workers with respect to controls while AGE levels were not different. Finally serum level of AOPPs and AGE were not correlated with the different GTS genotypes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzeno
/
Exposição Ocupacional
/
Estresse Oxidativo
/
Predisposição Genética para Doença
Limite:
Humans
Idioma:
It
Revista:
G Ital Med Lav Ergon
Assunto da revista:
MEDICINA OCUPACIONAL
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Itália