Early compaction at day 3 may be a useful additional criterion for embryo transfer.
J Assist Reprod Genet
; 30(5): 683-90, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23563915
ABSTRACT
PURPOSE:
The reduction of the number of embryos transferred while maintaining a satisfactory rate of pregnancy (PR) with in vitro fertilization calls for a refined technique of embryonic selection. This prospective study investigates the significance of early embryonic compaction at day 3 as a marker of the chances of implantation.METHODS:
We examined 317 transfers and their outcome involving 509 embryos including 91 compacted embryos.RESULTS:
Early compaction seems linked with the ovarian response to stimulation and embryonic quality. The PR is significantly increased when the embryonic cohort contains at least one compacted embryo (44% versus 29.5%, p = 0.01), and when at least one compacted embryo is transferred (44% versus 31%, p < 0.05). The analysis of our single embryo transfers shows that the implantation rates are significantly better for compacted embryos (50% versus 30%, p < 0.05) (OR 2.98; CI 1.02-5.28).CONCLUSION:
Thus, early compaction, sometimes observed at day 3, may serve as a useful additional criterion for selecting the embryos transferred.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Blastômeros
/
Fase de Clivagem do Zigoto
/
Embrião de Mamíferos
/
Transferência Embrionária
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
J Assist Reprod Genet
Assunto da revista:
GENETICA
/
MEDICINA REPRODUTIVA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
França