MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis.
J Neurosci
; 33(16): 6857-63, 2013 Apr 17.
Article
em En
| MEDLINE
| ID: mdl-23595744
ABSTRACT
Blood-brain barrier (BBB) dysfunction is a major hallmark of many neurological diseases, including multiple sclerosis (MS). Using a genomics approach, we defined a microRNA signature that is diminished at the BBB of MS patients. In particular, miR-125a-5p is a key regulator of brain endothelial tightness and immune cell efflux. Our findings suggest that repair of a disturbed BBB through microRNAs may represent a novel avenue for effective treatment of MS.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Barreira Hematoencefálica
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MicroRNAs
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Células Endoteliais
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Inflamação
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Esclerose Múltipla
Limite:
Humans
Idioma:
En
Revista:
J Neurosci
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Holanda