[Regulation of Toll-like receptors-dependent inflammatory response]. / Regulacja odpowiedzi zapalnej zaleznej od receptorów Toll-podobnych.
Postepy Hig Med Dosw (Online)
; 67: 201-13, 2013 Mar 25.
Article
em Pl
| MEDLINE
| ID: mdl-23619219
ABSTRACT
Toll-like receptors (TLRs) are a pivotal part of our innate immune response. They recognize a wide variety of pathogens and instigate an immune response, thus facilitating the removal of the disease-causing agent. Due to the intense nature of this response its strict control is of key importance, as a prolonged inflammatory signal leads to carcinogenesis and autoimmune disorders. The signaling cascade initiated by the activated TLR is complex and consists of multiple stages. It involves a variety of adaptor proteins, protein kinases and effector transcription factors. The number of stages in this process enables many possible checkpoints and ways of regulation. Signal modulation involves differentiated expression of TLRs, splicing variants of their adaptor proteins, enzymes modifying proteins engaged in the cascade and many more. This review focuses on endogenous factors responsible for controlling the TLR-dependent inflammatory response as well as on pharmacological therapies designed for regulating the innate immune response.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Receptores Toll-Like
/
Inflamação
Limite:
Humans
Idioma:
Pl
Revista:
Postepy Hig Med Dosw (Online)
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
MEDICINA
/
SAUDE PUBLICA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Polônia