[Differences in the expression of blood group antigens A and B in carcinoma of the stomach in relation to Laurén's classification]. / Rozdíly v expresi krevních skupinových antigenu A a B v karcinomu zaludku s prihlédnutím k Laurénove klasifikaci.

ABSTRACT

Expression of blood group antigens A and B was studied in a group of 48 gastric carcinomas (classified according to Laurén as intestinal and diffuse types respectively) by monoclonal antibodies in an indirect immunoperoxidase method. Results could be summarized as followings 1. Significant difference concerned the expression of blood group antigens A and AB. Intestinal type was characterized by striking heterogeneity of expression and more pronounced deletion of antigens. Diffuse type had a homogenous expression and a distinctly smaller deletion. 2. Supranuclear immunoreactivity with monoclonal antibody HE 10 in intestinal type carcinoma may have a prognostic importance. This expression could not be observed in diffuse type carcinoma.