Enhancement of affective processing induced by bifrontal transcranial direct current stimulation in patients with major depression.
Neuromodulation
; 17(2): 138-42, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-23710817
ABSTRACT
OBJECTIVE:
Our aim was to evaluate whether one single section of transcranial direct current stimulation (tDCS), a neuromodulatory technique that noninvasively modifies cortical excitability, could induce acute changes in the negative attentional bias in patients with major depression. SUBJECTS ANDMETHODS:
Randomized, double-blind, sham-controlled, parallel design enrolling 24 age-, gender-matched, drug-free, depressed subjects. Anode and cathode were placed over the left and right dorsolateral prefrontal cortex. We performed a word Emotional Stroop Task collecting the response times (RTs) for positive-, negative-, and neutral-related words. The emotional Stroop effect for negative vs. neutral and vs. positive words was used as the measure of attentional bias.RESULTS:
At baseline, RTs were significantly slower for negative vs. positive words. We found that active but not sham tDCS significantly modified the negative attentional bias, abolishing slower RT for negative words.CONCLUSION:
Active but not sham tDCS significantly modified the negative attentional bias. These findings add evidence that a single tDCS session transiently induces potent changes in affective processing, which might be one of the mechanisms of tDCS underlying mood changes.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tempo de Reação
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Córtex Pré-Frontal
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Transtorno Depressivo Maior
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Estimulação Magnética Transcraniana
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Neuromodulation
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Brasil