Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons.
Toxicon
; 75: 108-21, 2013 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-23817019
Palavras-chave
100 kDa heavy chain; 25 kDa C-terminal half of H(C); 25 kDa N-terminal half of H(C); 50 kDa C-terminal half of HC of CNTs; 50 kDa N-terminal half of HC; 50 kDa light chain; BBB; BoNT; BoNT/A hydrolyzed SNAP-25 comprising aa 1197; Botulinum neurotoxin; CD; CNS; CNT; Cell binding domain; Central neuron; GBS; H(C)X; H(CC); H(CN); H(N); HC; Hybrid; LC; MPN; NMJ; Neuromuscular junction; SDS-PAGE; SNAP-25; SNAP-25*A; SNARE; SV; SV2; Syt-X; TeNT; Tetanus neurotoxin; bloodbrain-barrier; botulinum neurotoxin; central nervous system; circular dichroism; clostridial neurotoxin; ganglioside binding site; isoform X of synaptotagmin; mouse phrenic nerve; neuromuscular junction; sodium dodecyl sulfate-polyacrylamide gel electrophoresis; soluble NSF attachment protein receptor; synaptic vesicle; synaptic vesicle glycoprotein 2; synaptosomal associated protein of 25 kDa; tetanus neurotoxin
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxina Tetânica
/
Toxinas Botulínicas
/
Metaloendopeptidases
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Toxinas Botulínicas Tipo A
/
Junção Neuromuscular
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Toxicon
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Alemanha