Unique peptide-binding motif for Mamu-B*037:01: an MHC class I allele common to Indian and Chinese rhesus macaques.
Immunogenetics
; 65(12): 897-900, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24042460
ABSTRACT
Indian and Chinese rhesus macaques are often used in biomedical research. Genetic analyses of the major histocompatibility class I region have revealed that these macaques display a substantial level of polymorphism at Mamu-A and Mamu-B loci, which have been subject to duplication. Only a few Mamu class I allotypes are characterised for their peptide-binding motifs, although more information of this nature would contribute to a better interpretation of T cell-mediated immune responses. Here, we present the results of the characterisation of the functional properties of Mamu-B*03701, an allotype commonly encountered in rhesus macaques of Indian and Chinese origin. Mamu-B*03701 is seen to have a strong preference for acidic amino acids at the third residue, and for arginine, lysine, and tyrosine at the carboxyl terminus. This peptide-binding motif is not described in the human population.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Genes MHC da Classe II
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Motivos de Aminoácidos
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Macaca mulatta
Limite:
Animals
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Immunogenetics
Ano de publicação:
2013
Tipo de documento:
Article