The effects of exposure to titanium dioxide nanoparticles during lactation period on learning and memory of rat offspring.
Toxicol Ind Health
; 32(2): 221-8, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-24081627
ABSTRACT
Nanoscale titanium dioxide (TiO2), which is massively produced and widely used in living environment, seems to have a potential risk on human health. The central nervous system (CNS) is the potential susceptible target of nanoparticles, but the studies on this aspect are limited so far. The aim of this study was to evaluate the effects of exposure to TiO2 nanoparticles during lactation period on learning and memory of offspring. Lactating Wistar rats were exposed to TiO2 nanoparticles (100 mg/kg; gavage) for 21 days. The Morris water maze and passive avoidance tests showed that the exposure to TiO2 nanoparticles could significantly impair the memory and learning in the offspring. Therefore, the application of TiO2 nanoparticles and the effects of their exposure, especially during developmental period on human brain should be cautious.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Titânio
/
Lactação
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Aprendizagem em Labirinto
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Exposição Materna
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Nanopartículas
/
Memória
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Toxicol Ind Health
Assunto da revista:
MEDICINA OCUPACIONAL
/
TOXICOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article