C-type lectin receptors mRNA expression in patients with otitis media with effusion.
Int J Pediatr Otorhinolaryngol
; 77(11): 1846-51, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24094722
ABSTRACT
OBJECTIVE:
The role of C-type lectin receptor, a type of pattern recognition receptor, in otitis media with effusion (OME) is unclear. We assayed the levels of expression of C-type lectin receptor mRNA in children with OME and evaluated its relationship to the presence of bacteria, accompanying diseases, and characteristics of exudates. SUBJECTS ANDMETHODS:
The study population consisted of 73 children with OME who had undergone ventilating tube insertion. The levels of expression of Dectin-1, MR1, MR2, DC-SIGN, Syk, Card-9, Bcl-10, Malt-1, Src, Dec-205, Galectin-1, Tim-3, Trem-1, and DAP-12 mRNA in middle ear effusion were determined by real-time PCR. The level of expression of each mRNA was correlated with the presence of bacteria, accompanying diseases, and exudates characteristics.RESULTS:
The levels of expression of C-type lectin receptor mRNAs were not associated with bacterial presence or exudates characteristics (p>0.05 each). Levels of expression, however, were significantly higher in patients with sinusitis, adenoid vegetation or adenoiditis, and allergic rhinitis (p<0.05 each).CONCLUSIONS:
Levels of expression of C-type lectin receptor mRNA may be associated with the pathogenesis of OME, being significantly higher in patients with than without accompanying sinusitis, adenoid vegetation or adenoiditis, and allergic rhinitis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Otite Média com Derrame
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RNA Mensageiro
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Rinite Alérgica Sazonal
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Predisposição Genética para Doença
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Lectinas Tipo C
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
Limite:
Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
Int J Pediatr Otorhinolaryngol
Ano de publicação:
2013
Tipo de documento:
Article