Discovery of 2-methylpyridine-based biaryl amides as Î³-secretase modulators for the treatment of Alzheimer's disease.

Chen, Jian Jeffrey; Qian, Wenyuan; Biswas, Kaustav; Yuan, Chester; Amegadzie, Albert; Liu, Qingyian; Nixey, Thomas; Zhu, Joe; Ncube, Mqhele; Rzasa, Robert M; Chavez, Frank; Chen, Ning; DeMorin, Frenel; Rumfelt, Shannon; Tegley, Christopher M; Allen, Jennifer R; Hitchcock, Stephen; Hungate, Randy; Bartberger, Michael D; Zalameda, Leeanne; Liu, Yichin; McCarter, John D; Zhang, Jianhua; Zhu, Li; Babu-Khan, Safura; Luo, Yi; Bradley, Jodi; Wen, Paul H; Reid, Darren L; Koegler, Frank; Dean, Charles; Hickman, Dean; Correll, Tiffany L; Williamson, Toni; Wood, Stephen

Chen, Jian Jeffrey; Qian, Wenyuan; Biswas, Kaustav; Yuan, Chester; Amegadzie, Albert; Liu, Qingyian; Nixey, Thomas; Zhu, Joe; Ncube, Mqhele; Rzasa, Robert M; Chavez, Frank; Chen, Ning; DeMorin, Frenel; Rumfelt, Shannon; Tegley, Christopher M; Allen, Jennifer R; Hitchcock, Stephen; Hungate, Randy; Bartberger, Michael D; Zalameda, Leeanne; Liu, Yichin; McCarter, John D; Zhang, Jianhua; Zhu, Li; Babu-Khan, Safura; Luo, Yi; Bradley, Jodi; Wen, Paul H; Reid, Darren L; Koegler, Frank; Dean, Charles; Hickman, Dean; Correll, Tiffany L; Williamson, Toni; Wood, Stephen.

Afiliação

Chen JJ; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States. Electronic address: jianc@amgen.com.

Bioorg Med Chem Lett ; 23(23): 6447-54, 2013 Dec 01.

Article em En | MEDLINE | ID: mdl-24139583

Assuntos

Doença de Alzheimer/tratamento farmacológico; Amidas/farmacologia; Secretases da Proteína Precursora do Amiloide/metabolismo; Picolinas/farmacologia; Doença de Alzheimer/enzimologia; Amidas/química; Animais; Células HEK293; Humanos; Picolinas/química; Ratos; Ratos Sprague-Dawley

Palavras-chave

Alzheimer's disease (AD); Amide as sulfonamide replacement; Amyloid ß-protein (Aß); Methylpyridine; Î³-Secretase inhibitor (GSI); Î³-Secretase modulator (GSM)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Picolinas / Secretases da Proteína Precursora do Amiloide / Doença de Alzheimer / Amidas Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2013 Tipo de documento: Article

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