New constituents from the Korean sponge Plakortis simplex.

Oh, Jung Soon; Hwang, Buyng Su; Kang, Ok-Hwa; Kwon, Dong-Yeul; Rho, Jung-Rae

Oh, Jung Soon; Hwang, Buyng Su; Kang, Ok-Hwa; Kwon, Dong-Yeul; Rho, Jung-Rae.

Afiliação

Oh JS; Department of Oceanography, Kunsan National University, Jeonbuk 573-701, Korea. jrrho@kunsan.ac.kr.

Mar Drugs ; 11(11): 4407-18, 2013 Nov 05.

Article em En | MEDLINE | ID: mdl-24196396

ABSTRACT

ABSTRACT

Six new cyclic peroxides (1-6) were isolated from the Korean sponge Plakortis simplex, along with two new alkylpyridinium alkaloids (7 and 8). The structures of these compounds were completely determined by a combination of NMR analysis and chemical reactions. Compounds 1-6 exhibited cytotoxic/antifungal activities against RAW264.7 cells and Candida albicans.

Assuntos

Peróxidos/química; Peróxidos/farmacologia; Plakortis/química; Poríferos/química; Alcaloides/química; Animais; Antifúngicos/química; Antifúngicos/farmacocinética; Candida albicans/efeitos dos fármacos; Células Cultivadas; Camundongos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peróxidos / Poríferos / Plakortis Limite: Animals Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2013 Tipo de documento: Article

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