[Myeloperoxidase in the neurodegenerative process of Parkinson's disease]. / Neurodegenerativer Prozess bei Morbus Parkinson: Rolle der Myeloperoxidase.
Dtsch Med Wochenschr
; 139(3): 99-102, 2014 Jan.
Article
em De
| MEDLINE
| ID: mdl-24277448
ABSTRACT
Myeloperoxidase (MPO) is a hemoprotein which is involved in the unspecific immune response. In this process hypochloric acid is released. Hypochloric acid can react with lipids and proteins and thus lead to cell damage. We were able to show that MPO, as well as a biomarker for MPO - 3-Chlorotyrosine - are upregulated in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-model of Parkinson's disease as well as in the disease itself. Ablation of MPO resulted in a neuroprotective effect in the MPTP-model. Herein we describe the different function of MPO, and how these can lead to the cellular demise as seen in Parkinson's disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Peroxidase
/
Degeneração Neural
Limite:
Animals
/
Humans
Idioma:
De
Revista:
Dtsch Med Wochenschr
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Reino Unido