[Biomarkers of effect and susceptibility to low doses of benzene]. / Indicatori di effetto e di suscettibilità alle basse dosi di benzene.
G Ital Med Lav Ergon
; 35(4): 259-62, 2013.
Article
em It
| MEDLINE
| ID: mdl-24303707
ABSTRACT
Current occupational exposure levels to benzene are reduced by three orders of magnitudo (from ppm to ppb) as compared to the past. As benzene toxicity is related to its biotransformation and bioactivation pathways seem to be more active at lower exposure levels, observed effects could be higher than expected. Although the genetic polymorphisms of relevant and functional metabolic enzymes are implied in the modulation of either the risk of adverse effects [myeloperoxidase and NAD(P)Hquinone oxidoreductase] or of the biomarkers of internal dose (glutathione S-transferases M1-1, T1-1, A1-1), they are not appliable as biomarkers of susceptibility. Among biomarkers of early effect, only the longitudinal monitoring of blood cell count seems suitable to be applied in health surveillance protocols, whereas the use of biomarkers of genotoxic effect at current exposure levels is at the present not supported by literature data.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzeno
/
Exposição Ocupacional
Limite:
Humans
Idioma:
It
Revista:
G Ital Med Lav Ergon
Assunto da revista:
MEDICINA OCUPACIONAL
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Itália