Dipeptidyl peptidase-4 inhibitor ameliorates early renal injury through its anti-inflammatory action in a rat model of type 1 diabetes.

Kodera, Ryo; Shikata, Kenichi; Takatsuka, Tetsuharu; Oda, Kaori; Miyamoto, Satoshi; Kajitani, Nobuo; Hirota, Daisho; Ono, Tetsuichiro; Usui, Hitomi Kataoka; Makino, Hirofumi

Kodera, Ryo; Shikata, Kenichi; Takatsuka, Tetsuharu; Oda, Kaori; Miyamoto, Satoshi; Kajitani, Nobuo; Hirota, Daisho; Ono, Tetsuichiro; Usui, Hitomi Kataoka; Makino, Hirofumi.

Afiliação

Kodera R; Center for Innovative Clinical Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. Electronic address: kodera@cc.okayama-u.ac.jp.
Shikata K; Center for Innovative Clinical Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan; Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,
Takatsuka T; Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Oda K; Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Miyamoto S; Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Kajitani N; Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Hirota D; Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Ono T; Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Usui HK; Department of Primary Care and Medical Education, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Makino H; Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.

Biochem Biophys Res Commun ; 443(3): 828-33, 2014 Jan 17.

Article em En | MEDLINE | ID: mdl-24342619

Assuntos

Anti-Inflamatórios/uso terapêutico; Diabetes Mellitus Experimental/tratamento farmacológico; Diabetes Mellitus Tipo 1/tratamento farmacológico; Inibidores da Dipeptidil Peptidase IV/uso terapêutico; Nefropatias/tratamento farmacológico; Adamantano/análogos & derivados; Adamantano/farmacologia; Adamantano/uso terapêutico; Animais; Anti-Inflamatórios/farmacologia; AMP Cíclico/urina; Diabetes Mellitus Experimental/complicações; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Experimental/patologia; Diabetes Mellitus Tipo 1/complicações; Diabetes Mellitus Tipo 1/metabolismo; Diabetes Mellitus Tipo 1/patologia; Nefropatias Diabéticas/sangue; Nefropatias Diabéticas/complicações; Nefropatias Diabéticas/tratamento farmacológico; Nefropatias Diabéticas/patologia; Inibidores da Dipeptidil Peptidase IV/farmacologia; Modelos Animais de Doenças; Peptídeo 1 Semelhante ao Glucagon/sangue; Nefropatias/complicações; Nefropatias/metabolismo; Nefropatias/patologia; Glomérulos Renais/efeitos dos fármacos; Glomérulos Renais/patologia; Masculino; Nitrilas/farmacologia; Nitrilas/uso terapêutico; Substâncias Protetoras/farmacologia; Substâncias Protetoras/uso terapêutico; Pirrolidinas/farmacologia; Pirrolidinas/uso terapêutico; Ratos; Ratos Sprague-Dawley

Palavras-chave

CD; CRP; DPP-4; Diabetic nephropathy; Dipeptidyl peptidase-4 inhibitor; GIP; GLP-1; ICAM-1; IL; Inflammation; Macrophage; NF-κB; PAM; SD; SpragueDawley; TGF-ß; TNF-α; c-reactive protein; cAMP; cluster of differentiation; cyclic AMP; dipeptidyl peptidase-4; gastric inhibitory polypeptide; glucagon-like peptide-1; intercellular adhesion molecule-1; interleukin; nuclear factor-κB; periodic acid-methenamine silver; transforming growth factor-ß; tumor necrosis factor-α

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 1 / Inibidores da Dipeptidil Peptidase IV / Nefropatias / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2014 Tipo de documento: Article

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