Regenerating Mandibular Bone Using rhBMP-2: Part 1-Immediate Reconstruction of Segmental Mandibulectomies.
Vet Surg
; 44(4): 403-9, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-24410740
ABSTRACT
OBJECTIVE:
To describe a surgical technique using a regenerative approach and internal fixation for immediate reconstruction of critical size bone defects after segmental mandibulectomy in dogs. STUDYDESIGN:
Prospective case series. ANIMALS Dogs (n = 4) that had reconstruction after segmental mandibulectomy for treatment of malignant or benign tumors.METHODS:
Using a combination of extraoral and intraoral approaches, a locking titanium plate was contoured to match the native mandible. After segmental mandibulectomy, the plate was secured and a compression resistant matrix (CRM) infused with rhBMP-2, implanted in the defect. The implant was then covered with a soft tissue envelope followed by intraoral and extraoral closure.RESULTS:
All dogs that had mandibular reconstruction healed with intact gingival covering over the mandibular defect and had immediate return to normal function and occlusion. Mineralized tissue formation was observed clinically within 2 weeks and solid cortical bone formation within 3 months. CT findings at 3 months showed that the newly regenerated mandibular bone had â¼50% of the bone density and porosity compared to the contralateral side. No significant complications occurred.CONCLUSION:
Mandibular reconstruction using internal fixation and CRM infused with rhBMP-2 is an excellent solution for immediate reconstruction of segmental mandibulectomy defects in dogs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Transformador beta
/
Proteína Morfogenética Óssea 2
/
Osteotomia Mandibular
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Mandíbula
Tipo de estudo:
Observational_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Vet Surg
Ano de publicação:
2015
Tipo de documento:
Article