Characterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection.

Larrea, Esther; Echeverria, Itziar; Riezu-Boj, Jose-I; Aldabe, Rafael; Guembe, Laura; Sola, Iosu; Civeira, María Pilar; Sarobe, Pablo; Prieto, Jesus

Larrea, Esther; Echeverria, Itziar; Riezu-Boj, Jose-I; Aldabe, Rafael; Guembe, Laura; Sola, Iosu; Civeira, María Pilar; Sarobe, Pablo; Prieto, Jesus.

Afiliação

Larrea E; Division of Hepatology and Gene Therapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain. Electronic address: elarrea@unav.es.
Echeverria I; Division of Hepatology and Gene Therapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Riezu-Boj JI; Division of Hepatology and Gene Therapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Aldabe R; Division of Hepatology and Gene Therapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Guembe L; Department of Morphology, CIMA, University of Navarra, Pamplona, Spain.
Sola I; University Clinic of Navarra, University of Navarra, Pamplona, Spain.
Civeira MP; University Clinic of Navarra, University of Navarra, Pamplona, Spain.
Sarobe P; Division of Hepatology and Gene Therapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Prieto J; Division of Hepatology and Gene Therapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain; University Clinic of Navarra, University of Navarra, Pamplona, Spain; CIBERehd, University of Navarra, Pamplona, Spain. Electronic address: jprieto@unav.es.

J Hepatol ; 60(3): 482-9, 2014 Mar.

Article em En | MEDLINE | ID: mdl-24418171

Assuntos

Ligante de CD40/fisiologia; Hepatite C Crônica/imunologia; Subunidade beta de Receptor de Oncostatina M/fisiologia; Oncostatina M/fisiologia; Células Apresentadoras de Antígenos/imunologia; Linfócitos T CD4-Positivos/imunologia; Humanos; Monócitos/imunologia; Fator de Transcrição STAT3/fisiologia

Palavras-chave

APC; CD40 ligand; CD40L; CHC; CLC; DCs; HCV; IFN; LIFR; LPS; MoDCs; OSM; OSM receptor beta subunit; OSMRß; PBMC; PGN; Poly I:C; RT-PCR; SVR; TLR; antigen presenting cells; cardiotrophin-like-cytokine; chronic hepatitis C; dendritic cells; hepatitis C virus; interferon; leukemia inhibitory factor receptor; lipopolysaccharide; monocyte-derived-DCs; oncostatin M; peptidoglycan; peripheral mononuclear cells; polyinosinic:polycytidylic acid; qPCR; quantitative real time PCR; reverse transcription polymerase chain reaction; sustained virological response; toll-like receptors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite C Crônica / Ligante de CD40 / Oncostatina M / Subunidade beta de Receptor de Oncostatina M Limite: Humans Idioma: En Revista: J Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2014 Tipo de documento: Article

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