Transcoronary gradient of plasma microRNA 423-5p in heart failure: evidence of altered myocardial expression.
Biomarkers
; 19(2): 135-41, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24506564
ABSTRACT
CONTEXT Elevated plasmatic microRNAs (miRs) are observed in heart failure (HF). However, the cardiac origin of these miRs remains unclear. OBJECTIVE:
We calculated transcoronary gradients of miR-29b, miR-133a and miR-423-5p in 17 outpatients with stable systolic HF and in controls without structural cardiac disease. MATERIALS ANDMETHODS:
MicroRNAs were measured by quantitative real-time polymerase chain reaction.RESULTS:
Positive transcoronary miR gradients were observed in patients with HF but not in controls (p = 0.03). B-type natriuretic peptide (BNP) moderately correlated with the transcoronary gradients of miR-133a and miR-423-5p. DISCUSSION ANDCONCLUSIONS:
The difference in transcoronary gradients between HF outpatients and controls suggests that miR-423-5p has a cardiac origin. The positive correlation between miR-423-5p and BNP transcoronary gradients supports this hypothesis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
MicroRNAs
/
Insuficiência Cardíaca
/
Miocárdio
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Biomarkers
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2014
Tipo de documento:
Article