Antioxidant and hepatoprotective effects of naringenin and its ß-cyclodextrin formulation in mice intoxicated with carbon tetrachloride: a comparative study.
J Med Food
; 17(6): 670-7, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24611872
ABSTRACT
The present study evaluated the antioxidant and hepatoprotective effects of the flavonoid naringenin (NGN) and its ß-cyclodextrin formulation at a dose of 50 mg/kg b.w. The assessment was done by the investigation of serum-enzymatic and liver antioxidant activity, histopathological and ultrastructural changes in male Swiss mice, which were subjected to acute experimental intoxication with CCl4. Formulated and free flavonoid were orally given to mice for 7 days and then were intraperitoneally injected with 1.0 mL/kg CCl4 on the 8th day. After 24 h of CCl4 administration, an increase in the levels of transaminases aspartate aminotransferase and alanine aminotransferase activities and malondialdehyde concentration occurred and a significant decrease in superoxide dismutase, catalase glutathione-peroxidase activities, and glutathione levels was detected as well. These were accompanied by extended centrilobular necrosis, steatosis, fibrosis, and an altered ultrastructure of hepatocytes. Pretreatment with formulated or free flavonoid retained the biochemical markers to control values. Histopathological and electron-microscopic examination confirmed the biochemical results. In conclusion, both NGN and NGN/ß-cyclodextrin complex showed antioxidant and hepatoprotective effects against injuries induced by CCl4.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
/
Flavanonas
/
Beta-Ciclodextrinas
/
Doença Hepática Induzida por Substâncias e Drogas
/
Fígado
/
Fitoterapia
/
Antioxidantes
Limite:
Animals
Idioma:
En
Revista:
J Med Food
Assunto da revista:
CIENCIAS DA NUTRICAO
/
MEDICINA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Romênia