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Involvement of deleted chromosome 5 in complex chromosomal aberrations in newly diagnosed myelodysplastic syndromes (MDS) is correlated with extremely adverse prognosis.
Zemanova, Zuzana; Michalova, Kyra; Buryova, Halka; Brezinova, Jana; Kostylkova, Karla; Bystricka, Dagmar; Novakova, Milena; Sarova, Iveta; Izakova, Silvia; Lizcova, Libuse; Ransdorfova, Sarka; Krejcik, Zdenek; Merkerova, Michaela Dostalova; Dohnalova, Alena; Siskova, Magda; Jonasova, Anna; Neuwirtova, Radana; Cermak, Jaroslav.
Afiliação
  • Zemanova Z; Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic. Electronic address: zuze@vfn.cz.
  • Michalova K; Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic; Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
  • Buryova H; Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic.
  • Brezinova J; Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
  • Kostylkova K; Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic.
  • Bystricka D; Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic.
  • Novakova M; Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic.
  • Sarova I; Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
  • Izakova S; Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic.
  • Lizcova L; Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic.
  • Ransdorfova S; Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
  • Krejcik Z; Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
  • Merkerova MD; Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
  • Dohnalova A; Institute of Physiology, First Faculty of Medicine, Charles University in Prague, Czech Republic.
  • Siskova M; First Medical Department, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic.
  • Jonasova A; First Medical Department, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic.
  • Neuwirtova R; First Medical Department, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic.
  • Cermak J; Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
Leuk Res ; 38(5): 537-44, 2014 May.
Article em En | MEDLINE | ID: mdl-24636338
ABSTRACT
MDS with complex chromosomal aberrations (CCA) are characterized by short survival and a high rate of transformation to AML. A comprehensive genome-wide analysis of bone-marrow cells of 157 adults with newly diagnosed MDS and CCA revealed a large spectrum of nonrandom genomic changes related to the advanced stages of MDS. Chromosome shattering, probably resulting from chromothripsis, was found in 47% of patients. Deleted chromosome 5 was unstable and often involved in different types of cryptic unbalanced rearrangements. No true monosomy 5 was observed. Patients with CCA involving deleted chromosome 5 had an extremely poor prognosis (median overall survival, 2 months).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes Mielodisplásicas / Cromossomos Humanos Par 5 / Deleção Cromossômica Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Leuk Res Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes Mielodisplásicas / Cromossomos Humanos Par 5 / Deleção Cromossômica Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Leuk Res Ano de publicação: 2014 Tipo de documento: Article