Congenic strain differences of renal malformations in ACI/Mna rats by introgression of the chromosomal region of BUF/Mna rats containing Pur1.
Nagoya J Med Sci
; 75(3-4): 251-4, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-24640181
ABSTRACT
The ACI rats developed hereditary renal malformations including agenesis and hydronephrosis at moderate penetrance. During construction of a variety of congenic strains based on ACI/Mna (ACI), BUF/Mna (BUF), and WKY/NCrj (WKY) rats, we found that the renal malformations were significantly suppressed by introgression of a segment of chromosome 13 of BUF rats containing Pur1 locus. It is plausible that this region contain a modifier locus influencing development of renal malformations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mapeamento Cromossômico
/
Cromossomos
/
Animais Congênicos
/
Rim
/
Nefropatias
Limite:
Animals
Idioma:
En
Revista:
Nagoya J Med Sci
Ano de publicação:
2013
Tipo de documento:
Article