Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis.

Rops, Angelique L W M M; Loeven, Markus A; van Gemst, Jasper J; Eversen, Iris; Van Wijk, Xander M; Dijkman, Henry B; van Kuppevelt, Toin H; Berden, Jo H M; Rabelink, Ton J; Esko, Jeffrey D; van der Vlag, Johan

Rops, Angelique L W M M; Loeven, Markus A; van Gemst, Jasper J; Eversen, Iris; Van Wijk, Xander M; Dijkman, Henry B; van Kuppevelt, Toin H; Berden, Jo H M; Rabelink, Ton J; Esko, Jeffrey D; van der Vlag, Johan.

Afiliação

Rops AL; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
Loeven MA; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
van Gemst JJ; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
Eversen I; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
Van Wijk XM; Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, California, USA.
Dijkman HB; Department of Pathology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
van Kuppevelt TH; Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
Berden JH; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
Rabelink TJ; Department of Nephrology and Einthoven Laboratory for Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands.
Esko JD; Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, California, USA.
van der Vlag J; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

Kidney Int ; 86(5): 932-42, 2014 Nov.

Article em En | MEDLINE | ID: mdl-24759151

Assuntos

Doença Antimembrana Basal Glomerular/metabolismo; Quimiotaxia de Leucócito; Células Endoteliais/metabolismo; Glicocálix/metabolismo; Heparitina Sulfato/metabolismo; Glomérulos Renais/metabolismo; Leucócitos/metabolismo; Animais; Doença Antimembrana Basal Glomerular/genética; Doença Antimembrana Basal Glomerular/imunologia; Doença Antimembrana Basal Glomerular/fisiopatologia; Doença Antimembrana Basal Glomerular/prevenção & controle; Autoanticorpos; Adesão Celular; Linhagem Celular; Quimiocinas/metabolismo; Técnicas de Cocultura; Modelos Animais de Doenças; Regulação para Baixo; Células Endoteliais/imunologia; Feminino; Glicocálix/imunologia; Glomérulos Renais/imunologia; Glomérulos Renais/fisiopatologia; Selectina L/metabolismo; Leucócitos/imunologia; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout; Interferência de RNA; Transdução de Sinais; Sulfotransferases/deficiência; Sulfotransferases/genética; Fatores de Tempo; Transfecção

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quimiotaxia de Leucócito / Glicocálix / Doença Antimembrana Basal Glomerular / Células Endoteliais / Heparitina Sulfato / Glomérulos Renais / Leucócitos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Kidney Int Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Holanda

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