Antimutagenic effects of taurine in a bacterial assay system.
Cancer Res
; 49(23): 6600-4, 1989 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-2479467
ABSTRACT
Taurine (2-aminoethanesulfonic acid) was evaluated as an antimutagen in the Ames Salmonella tester strain assay. Taurine inhibited mutagenesis by doxorubicin (-74%), bleomycin (-55%), mitomycin C (-56%), and 2-aminofluorene (-52%), but not danthrone or benzo(a)pyrene, in strain TA102. In strain TA98, doxorubicin mutagenicity, but not that of 2-aminofluorene or benzo(a)pyrene, was inhibited by taurine. N-Methyl-N'-nitro-N-nitrosoguanidine (-73%), but not dexon, mutagenicity was inhibited by taurine in strain TA100. Taurine inhibited those mutagens against which it was effective in a dose-related fashion. Taurine was more effective in inhibiting doxorubicin mutagenicity in strain TA102 than its analogues hypotaurine, beta-alanine, and guanidinoethanesulfonic acid or alanine or glycine. The observed inhibition may indicate a role for taurine in modulating the activity of oxidant species.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Taurina
/
Mutagênicos
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1989
Tipo de documento:
Article