Lipopeptides are signaled by Toll-like receptor 1, 2 and 6 in endolysosomes.

Motoi, Yuji; Shibata, Takuma; Takahashi, Koichiro; Kanno, Atsuo; Murakami, Yusuke; Li, Xiaobing; Kasahara, Tadashi; Miyake, Kensuke

Motoi, Yuji; Shibata, Takuma; Takahashi, Koichiro; Kanno, Atsuo; Murakami, Yusuke; Li, Xiaobing; Kasahara, Tadashi; Miyake, Kensuke.

Afiliação

Motoi Y; Division of Innate Immunity, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo 108-8639, Japan.
Shibata T; Division of Innate Immunity, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo 108-8639, Japan Laboratory of Innate Immunity, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokaned
Takahashi K; Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Saga University Medical School, 5-1-1 Nabeshima, Sagashi, Saga 849-8501, Japan.
Kanno A; Division of Innate Immunity, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo 108-8639, Japan.
Murakami Y; Division of Innate Immunity, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo 108-8639, Japan.
Li X; Division of Innate Immunity, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo 108-8639, Japan.
Kasahara T; Department of Biochemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minatoku, Tokyo 105-8512, Japan.
Miyake K; Division of Innate Immunity, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo 108-8639, Japan Laboratory of Innate Immunity, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokaned

Int Immunol ; 26(10): 563-73, 2014 Oct.

Article em En | MEDLINE | ID: mdl-24860120

Assuntos

Endossomos/metabolismo; Lipopeptídeos/metabolismo; Lisossomos/metabolismo; Transdução de Sinais; Receptor 1 Toll-Like/metabolismo; Receptor 2 Toll-Like/metabolismo; Receptor 6 Toll-Like/metabolismo; Animais; Anticorpos Monoclonais/farmacologia; Linfócitos B/metabolismo; Células da Medula Óssea/metabolismo; Membrana Celular/metabolismo; Células Dendríticas/metabolismo; Dinaminas/metabolismo; Endocitose/imunologia; Proteína 1 de Membrana Associada ao Lisossomo/metabolismo; Proteína 2 de Membrana Associada ao Lisossomo/metabolismo; Camundongos; Camundongos Knockout; Monócitos/metabolismo; Neutrófilos/metabolismo; Multimerização Proteica; Transporte Proteico; Ratos; Baço/citologia; Baço/metabolismo; Receptor 1 Toll-Like/antagonistas & inibidores; Receptor 1 Toll-Like/química; Receptor 2 Toll-Like/antagonistas & inibidores; Receptor 2 Toll-Like/química; Receptor 6 Toll-Like/antagonistas & inibidores; Receptor 6 Toll-Like/química

Palavras-chave

TLR2; cell surface expression; endolysosome; internalization; lipopeptides

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endossomos / Transdução de Sinais / Receptor 1 Toll-Like / Receptor 2 Toll-Like / Receptor 6 Toll-Like / Lipopeptídeos / Lisossomos Limite: Animals Idioma: En Revista: Int Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Japão

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