Neuromuscular junction disorders mimicking myopathy.
Muscle Nerve
; 50(5): 854-6, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-24862941
ABSTRACT
INTRODUCTION:
Small-amplitude, short-duration motor unit action potentials are non-specific findings seen in myopathies and neuromuscular junction (NMJ) disorders. NMJ studies (repetitive nerve stimulation and single-fiber electromyography) can determine if such findings are related to NMJ abnormalities but are not considered routinely in atypical cases.METHODS:
Medical records of 338 patients with confirmed NMJ disorders were reviewed to identify cases with a clinical or electrodiagnostic impression of myopathy during initial evaluation. A history of muscle biopsy with findings that did not support a myopathic process was required for inclusion.RESULTS:
Four patients met the inclusion criteria. NMJ studies were abnormal in all cases. One patient had elevated acetylcholine receptor antibodies. Three patients were antibody negative 2 demonstrated immunotherapy responsiveness, and 1 had a Rapsyn mutation.CONCLUSIONS:
NMJ disorders may mimic myopathies, and NMJ studies should be performed to clarify so-called "myopathic" electromyographic findings to avoid unnecessary testing and delayed diagnosis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças da Junção Neuromuscular
/
Doenças Musculares
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adolescent
/
Female
/
Humans
Idioma:
En
Revista:
Muscle Nerve
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos