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Design, synthesis and evaluation of phenethylaminoheterocycles as K(v)1.5 inhibitors.
Johnson, James A; Xu, Ningning; Jeon, Yoon; Finlay, Heather J; Kover, Alexander; Conder, Mary L; Sun, Huabin; Li, Danshi; Levesque, Paul; Hsueh, Mei-Mann; Harper, Timothy W; Wexler, Ruth R; Lloyd, John.
Afiliação
  • Johnson JA; Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08534-5400, USA. Electronic address: james.a.johnson@bms.com.
  • Xu N; Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08534-5400, USA.
  • Jeon Y; Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08534-5400, USA.
  • Finlay HJ; Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08534-5400, USA.
  • Kover A; Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08534-5400, USA.
  • Conder ML; Department of Discovery Biology, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08534-5400, USA.
  • Sun H; Department of Discovery Biology, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08534-5400, USA.
  • Li D; Department of Discovery Biology, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08534-5400, USA.
  • Levesque P; Department of Discovery Biology, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08534-5400, USA.
  • Hsueh MM; Department of Preclinical Candidate Optimization, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08534-5400, USA.
  • Harper TW; Department of Preclinical Candidate Optimization, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08534-5400, USA.
  • Wexler RR; Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08534-5400, USA.
  • Lloyd J; Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08534-5400, USA.
Bioorg Med Chem Lett ; 24(14): 3018-22, 2014 Jul 15.
Article em En | MEDLINE | ID: mdl-24881565
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbamatos / Desenho de Fármacos / Bloqueadores dos Canais de Potássio / Canal de Potássio Kv1.5 / Indazóis Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbamatos / Desenho de Fármacos / Bloqueadores dos Canais de Potássio / Canal de Potássio Kv1.5 / Indazóis Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article