Antimicrobial and P450 inhibitory properties of common functional foods.
J Pharm Pharm Sci
; 17(2): 254-65, 2014.
Article
em En
| MEDLINE
| ID: mdl-24934554
ABSTRACT
PURPOSE:
To study the effect of functional foods on human cytochrome P450 (CYP) and the gut bacterial microflora that may potentially affect drug metabolism and ultimately affect human health and wellness.METHODS:
This study examined a variety of food plants from the Apiaceae, Fabaceae, and Lamiaceae families for their inhibitory potential on cytochrome 2D6-, 3A4-, 3A5-, and 3A7-mediated metabolism. The antimicrobial effects of these samples were also investigated with 7 selected bacterial surrogate species to determine potential effects on the gut microflora.RESULTS:
The highest CYP inhibitory activities, based upon visual examination, were observed from extracts of celery seed, cumin, fennel seed, basil, oregano, and rosemary belonging to the Apiaceae and Lamiaceae families, respectively. Likewise, the strongest antimicrobial activities were also observed in the Apiaceae and Lamiaceae. No significant antimicrobial and CYP inhibition was observed in the Fabaceae extracts.CONCLUSION:
Results demonstrated the possible risk of food-drug interactions from spice and herb plants may affect drug disposition and safety.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Enzimático do Citocromo P-450
/
Alimento Funcional
/
Inibidores das Enzimas do Citocromo P-450
/
Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
J Pharm Pharm Sci
Assunto da revista:
FARMACIA
/
FARMACOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article