Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling.

Moreno, Estefanía; Andradas, Clara; Medrano, Mireia; Caffarel, María M; Pérez-Gómez, Eduardo; Blasco-Benito, Sandra; Gómez-Cañas, María; Pazos, M Ruth; Irving, Andrew J; Lluís, Carme; Canela, Enric I; Fernández-Ruiz, Javier; Guzmán, Manuel; McCormick, Peter J; Sánchez, Cristina

Moreno, Estefanía; Andradas, Clara; Medrano, Mireia; Caffarel, María M; Pérez-Gómez, Eduardo; Blasco-Benito, Sandra; Gómez-Cañas, María; Pazos, M Ruth; Irving, Andrew J; Lluís, Carme; Canela, Enric I; Fernández-Ruiz, Javier; Guzmán, Manuel; McCormick, Peter J; Sánchez, Cristina.

Afiliação

Moreno E; From the Department of Biochemistry and Molecular Biology, University of Barcelona, 08028 Barcelona, Spain, the Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain, the Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, S
Andradas C; the Department of Biochemistry and Molecular Biology I, School of Biology and the Instituto de Investigación Hospital 12 de Octubre, 28041 Madrid, Spain.
Medrano M; From the Department of Biochemistry and Molecular Biology, University of Barcelona, 08028 Barcelona, Spain, the Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain, the Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, S
Caffarel MM; the Department of Biochemistry and Molecular Biology I, School of Biology and.
Pérez-Gómez E; the Department of Biochemistry and Molecular Biology I, School of Biology and the Instituto de Investigación Hospital 12 de Octubre, 28041 Madrid, Spain.
Blasco-Benito S; the Department of Biochemistry and Molecular Biology I, School of Biology and the Instituto de Investigación Hospital 12 de Octubre, 28041 Madrid, Spain.
Gómez-Cañas M; the Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain, Department of Biochemistry and Molecular Biology III/Instituto Universitario de Investigación en Neuroquímica, School of Medicine, Complutense University, 28040 Madrid, Spain, the Institu
Pazos MR; the Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain, Department of Biochemistry and Molecular Biology III/Instituto Universitario de Investigación en Neuroquímica, School of Medicine, Complutense University, 28040 Madrid, Spain.
Irving AJ; the Division of Neuroscience, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, United Kingdom, and.
Lluís C; From the Department of Biochemistry and Molecular Biology, University of Barcelona, 08028 Barcelona, Spain, the Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain, the Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, S
Canela EI; From the Department of Biochemistry and Molecular Biology, University of Barcelona, 08028 Barcelona, Spain, the Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain, the Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, S
Fernández-Ruiz J; the Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain, Department of Biochemistry and Molecular Biology III/Instituto Universitario de Investigación en Neuroquímica, School of Medicine, Complutense University, 28040 Madrid, Spain, the Institu
Guzmán M; the Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain, the Department of Biochemistry and Molecular Biology I, School of Biology and the Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid 28034, Spain.
McCormick PJ; From the Department of Biochemistry and Molecular Biology, University of Barcelona, 08028 Barcelona, Spain, the Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain, the Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, S
Sánchez C; the Department of Biochemistry and Molecular Biology I, School of Biology and the Instituto de Investigación Hospital 12 de Octubre, 28041 Madrid, Spain, cristina.sanchez@quim.ucm.es.

J Biol Chem ; 289(32): 21960-72, 2014 Aug 08.

Article em En | MEDLINE | ID: mdl-24942731

Assuntos

Neoplasias/metabolismo; Receptor CB2 de Canabinoide/química; Receptor CB2 de Canabinoide/metabolismo; Receptores Acoplados a Proteínas G/química; Receptores Acoplados a Proteínas G/metabolismo; Animais; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/genética; Neoplasias da Mama/metabolismo; Canabinoides/metabolismo; Canabinoides/farmacologia; Linhagem Celular Tumoral; Dronabinol/farmacologia; Feminino; Marcação de Genes; Glioblastoma/tratamento farmacológico; Glioblastoma/genética; Glioblastoma/metabolismo; Células HEK293; Humanos; Masculino; Camundongos; Camundongos Nus; Neoplasias/tratamento farmacológico; Neoplasias/genética; Estrutura Quaternária de Proteína; RNA Interferente Pequeno/genética; Receptor CB2 de Canabinoide/genética; Receptores de Canabinoides; Receptores Acoplados a Proteínas G/genética; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Transdução de Sinais/efeitos dos fármacos; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Cancer; Cannabinoid; Cannabinoid Receptor; G Protein-coupled Receptor (GPCR); Signal Transduction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Acoplados a Proteínas G / Receptor CB2 de Canabinoide / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: J Biol Chem Ano de publicação: 2014 Tipo de documento: Article

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