Does pharmacotherapy influence the inflammatory responses during cardiopulmonary bypass in children?
J Cardiovasc Pharmacol
; 64(2): 191-7, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24949583
ABSTRACT
Cardiopulmonary bypass (CPB) induces a systemic inflammatory response syndrome (SIRS) by factors such as contact of the blood with the foreign surface of the extracorporeal circuit, hypothermia, reduction of pulmonary blood flow during CPB and endotoxemia. SIRS is maintained in the postoperative phase, co-occurring with a counter anti-inflammatory response syndrome. Research on the effects of drugs administered before the surgery, especially in the induction phase of anesthesia, as well as drugs used during extracorporeal circulation, has revealed that they greatly influence these postoperative inflammatory responses. A better understanding of these processes may not only improve postoperative recovery but also enable tailor-made pharmacotherapy, with both health and economic benefits. In this review, we describe the pathophysiology of SIRS and counter anti-inflammatory response syndrome in the light of CPB in children and the influence of drugs used on these syndromes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ponte Cardiopulmonar
/
Síndrome de Resposta Inflamatória Sistêmica
/
Analgésicos Opioides
/
Anestésicos
/
Anti-Inflamatórios
Limite:
Child
/
Humans
Idioma:
En
Revista:
J Cardiovasc Pharmacol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Holanda