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OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
Chen, Ligong; Shu, Yan; Liang, Xiaomin; Chen, Eugene C; Yee, Sook Wah; Zur, Arik A; Li, Shuanglian; Xu, Lu; Keshari, Kayvan R; Lin, Michael J; Chien, Huan-Chieh; Zhang, Youcai; Morrissey, Kari M; Liu, Jason; Ostrem, Jonathan; Younger, Noah S; Kurhanewicz, John; Shokat, Kevan M; Ashrafi, Kaveh; Giacomini, Kathleen M.
Afiliação
  • Chen L; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143-2911;Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China;
  • Shu Y; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143-2911;
  • Liang X; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143-2911;
  • Chen EC; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143-2911;
  • Yee SW; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143-2911;
  • Zur AA; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143-2911;
  • Li S; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143-2911;
  • Xu L; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143-2911;
  • Keshari KR; Department of Radiology and Biomedical Imaging, School of Medicine, University of California, San Francisco, CA 94143-2520;
  • Lin MJ; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143-2911;
  • Chien HC; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143-2911;
  • Zhang Y; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143-2911;
  • Morrissey KM; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143-2911;
  • Liu J; Department of Physiology, School of Medicine, University of California, San Francisco, CA 94143-2240;
  • Ostrem J; Department of Cellular and Molecular Pharmacology, School of Medicine, University of California, San Francisco, CA 94158-2280; and.
  • Younger NS; Department of Cellular and Molecular Pharmacology, School of Medicine, University of California, San Francisco, CA 94158-2280; and.
  • Kurhanewicz J; Department of Radiology and Biomedical Imaging, School of Medicine, University of California, San Francisco, CA 94143-2520;
  • Shokat KM; Department of Cellular and Molecular Pharmacology, School of Medicine, University of California, San Francisco, CA 94158-2280; and.
  • Ashrafi K; Department of Physiology, School of Medicine, University of California, San Francisco, CA 94143-2240;
  • Giacomini KM; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143-2911;Institute for Human Genetics, University of California, San Francisco, CA 94143 kathy.giacomini@ucsf.edu.
Proc Natl Acad Sci U S A ; 111(27): 9983-8, 2014 Jul 08.
Article em En | MEDLINE | ID: mdl-24961373
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiamina / Fator 1 de Transcrição de Octâmero / Fígado Gorduroso / Hipoglicemiantes / Metformina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiamina / Fator 1 de Transcrição de Octâmero / Fígado Gorduroso / Hipoglicemiantes / Metformina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2014 Tipo de documento: Article