Host cytokine responses induced after overnight stimulation with novel M. tuberculosis infection phase-dependent antigens show promise as diagnostic candidates for TB disease.

Essone, Paulin N; Chegou, Novel N; Loxton, Andre G; Stanley, Kim; Kriel, Magdalena; van der Spuy, Gian; Franken, Kees L; Ottenhoff, Tom H; Walzl, Gerhard

Essone, Paulin N; Chegou, Novel N; Loxton, Andre G; Stanley, Kim; Kriel, Magdalena; van der Spuy, Gian; Franken, Kees L; Ottenhoff, Tom H; Walzl, Gerhard.

Afiliação

Essone PN; DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Chegou NN; DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Loxton AG; DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Stanley K; DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Kriel M; DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
van der Spuy G; DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Franken KL; Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands.
Ottenhoff TH; Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands.
Walzl G; DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

PLoS One ; 9(7): e102584, 2014.

Article em En | MEDLINE | ID: mdl-25025278

Assuntos

Citocinas/sangue; Mycobacterium tuberculosis/imunologia; Tuberculose Pulmonar/sangue; Adolescente; Adulto; Antígenos de Bactérias/imunologia; Biomarcadores/sangue; Feminino; Humanos; Testes de Liberação de Interferon-gama; Masculino; Projetos Piloto; Curva ROC; Tuberculose Pulmonar/diagnóstico; Tuberculose Pulmonar/imunologia; Adulto Jovem

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Citocinas / Mycobacterium tuberculosis Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: África do Sul

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