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Synthesis and biological evaluation of substituted 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors.
Wang, Ling-xiao; Zhou, Xin-bo; Xiao, Meng-liang; Jiang, Ning; Liu, Feng; Zhou, Wen-xia; Wang, Xiao-kui; Zheng, Zhi-bing; Li, Song.
Afiliação
  • Wang LX; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, PR China.
  • Zhou XB; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, PR China.
  • Xiao ML; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, PR China.
  • Jiang N; Department of Traditional Chinese Materia Medica and Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, PR China.
  • Liu F; Department of Traditional Chinese Materia Medica and Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, PR China.
  • Zhou WX; Department of Traditional Chinese Materia Medica and Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, PR China.
  • Wang XK; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, PR China. Electronic address: wxkcaptain@aliyun.com.
  • Zheng ZB; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, PR China. Electronic address: zhengzb@bmi.ac.cn.
  • Li S; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, PR China.
Bioorg Med Chem Lett ; 24(16): 3739-43, 2014 Aug 15.
Article em En | MEDLINE | ID: mdl-25086680
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ftalazinas / Tiofenos / Inibidores Enzimáticos / Inibidores de Poli(ADP-Ribose) Polimerases Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ftalazinas / Tiofenos / Inibidores Enzimáticos / Inibidores de Poli(ADP-Ribose) Polimerases Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article