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Obesity is a determinant of arterial stiffness independent of traditional risk factors in Asians with young-onset type 2 diabetes.
Liu, Jian-Jun; Sum, Chee Fang; Tavintharan, Subramaniam; Yeoh, Lee Ying; Ng, Xiao Wei; Moh, Angela Mei Chung; Lee, Simon; Tang, Wern Ee; Lim, Su Chi.
Afiliação
  • Liu JJ; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828, Republic of Singapore.
  • Sum CF; Diabetes Centre, Khoo Teck Puat Hospital, Singapore 768828, Republic of Singapore; Department of Medicine, Khoo Teck Puat Hospital, Singapore 768828, Republic of Singapore.
  • Tavintharan S; Diabetes Centre, Khoo Teck Puat Hospital, Singapore 768828, Republic of Singapore; Department of Medicine, Khoo Teck Puat Hospital, Singapore 768828, Republic of Singapore.
  • Yeoh LY; Department of Medicine, Khoo Teck Puat Hospital, Singapore 768828, Republic of Singapore.
  • Ng XW; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828, Republic of Singapore.
  • Moh AM; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828, Republic of Singapore.
  • Lee S; Yishun Polyclinic, National Health Group, Singapore 768796, Republic of Singapore.
  • Tang WE; Yishun Polyclinic, National Health Group, Singapore 768796, Republic of Singapore.
  • Lim SC; Diabetes Centre, Khoo Teck Puat Hospital, Singapore 768828, Republic of Singapore; Department of Medicine, Khoo Teck Puat Hospital, Singapore 768828, Republic of Singapore. Electronic address: lim.su.chi@alexandrahealth.com.sg.
Atherosclerosis ; 236(2): 286-91, 2014 Oct.
Article em En | MEDLINE | ID: mdl-25112799
ABSTRACT

OBJECTIVE:

Type 2 diabetes (T2DM) among the young population has become a serious concern globally, presumably due to the rising trend of obesity. Compared to other forms of diabetes, young-onset T2DM experiences more cardiovascular events and other vascular complications although the underlying mechanisms remain largely unknown. Increased arterial stiffness is a hallmark of vasculopathy. We aim to study the clinical and metabolic determinants of arterial stiffness in a cohort of multi-ethnic Asians with young-onset T2DM.

METHODS:

179 subjects with T2DM onset age below 30 years old were selected in this cross sectional study. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (PWV).

RESULTS:

PWV was correlated with age, duration of diabetes, systolic blood pressure, alanine aminotransferase, urinary albumin-to-creatinine ratio (ACR) and eGFR in bivariate correlation analysis. However, PWV was only significantly correlated with body mass index (BMI), waist circumference, urinary ACR and eGFR after adjustment for age. Overweight individuals with young-onset T2DM had significantly higher PWV levels compared to their lean counterparts (7.3 ± 2.4 m/s vs 6.4 ± 2.3 m/s, p = 0.072 and p < 0.0001 without and with adjustment for age, respectively). Multivariable regression models revealed that age, BMI, eGFR and usage of insulin were independently associated with PWV. These 4 variables explained 35.5% variance in PWV levels.

CONCLUSION:

Age, BMI, renal function and insulin usage are the main determinants of PWV levels in Asians with young-onset T2DM. Notably, obesity is a modifiable determinant of arterial stiffness independent of high blood pressure, dyslipidemia and hyperglycemia in this population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Povo Asiático / Diabetes Mellitus Tipo 2 / Angiopatias Diabéticas / Rigidez Vascular / Obesidade Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Asia Idioma: En Revista: Atherosclerosis Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Povo Asiático / Diabetes Mellitus Tipo 2 / Angiopatias Diabéticas / Rigidez Vascular / Obesidade Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Asia Idioma: En Revista: Atherosclerosis Ano de publicação: 2014 Tipo de documento: Article